antibody

Anti-C. elegans SGO-1 Antibody

DZ41026

200 μl/vial

polyclonal

domestic rabbit

nonconjugated

Anti-C. elegans SGO-1 Antibody

200 μl/vial

Polyclonal

Rabbit

C. Elegans

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-SGO-1 Antibody catalog # DZ41026. This antibody reacts with C. elegans.

500 μg/ml

sgo-1

Q18412

Liquid

Each vial contains 20mM PBS, 50% glycerol, 0.02% NaN3.

Immunogen affinity purified.

No cross reactivity with other proteins.

At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.

Boster recommends HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene. Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.