Anti-Zebrafish Nap1l4b Antibody | Boster DZ33969-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Zebrafish Nap1l4b Antibody

catalog :

DZ33969-1

quantity :

200μl/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

zebrafish

product information

SKU :

DZ33969-1

Product Name :

Anti-Zebrafish Nap1l4b Antibody

Size :

200μl/vial

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

zebrafish

Application Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Polyclonal Anti-Nap1l4b Antibody catalog # DZ33969-1. This antibody reacts with Zebrafish.

Concentration :

500μg/ml

Gene Name :

nap1l4b

Uniprot ID :

Q5U3U9

Form :

Liquid

Contents :

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Purification :

Immunogen affinity purified.

Cross-reactivity :

No cross reactivity with other proteins.

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Gene Full Name :

SUMO specific peptidase 1

Synonyms :

Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SENP1

Protein Name :

Sentrin-specific protease 1

Protein Function :

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Deconjugates SUMO1 from METTL3. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2.

Subcellular Localization :

Nucleus. Cytoplasm.

Tissue Specificity :

Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Background :

Sentrin-specific protease 1 is a protein that in human is encoded by the SENP1 gene. This gene is mapped to 12q13.11. This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.

Research Category :

Signal Transduction