Anti-Vinculin VCL Antibody | Boster A30448 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Vinculin VCL Antibody

catalog :

A30448

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

product information

SKU :

A30448

Product Name :

Anti-Vinculin VCL Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, IHC, IF

Application Details :

User need to optimize the dilution ratio for this antibody

Description :

Boster Bio Anti-Vinculin VCL Antibody catalog # A30448. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

VCL

Uniprot ID :

P18206

Immunogen :

A peptide derived from human Vinculin. Immunogen sequence location: 786-835

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification :

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Vinculin

Synonyms :

Vinculin; Metavinculin; MV; VCL;

Molecular Weight :

123799 MW

Protein Function :

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Subcellular Localization :

Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cell junction, focal adhesion. Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Colocalizes with LIMD1 in the focal adhesions.

Tissue Specificity :

Metavinculin is muscle-specific.

Research Category :

Actin Binding Proteins, Actin Etc, Cardiovascular, Contractility, Cytoskeleton, Cytoskeleton / Ecm, Microfilaments, Signal Transduction