Anti-mei-41 Antibody | Boster A20047 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-mei-41 Antibody

catalog :

A20047

quantity :

100 ug/200 ul

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

fruit fly

application :

western blot

product information

sku :

A20047

name :

Anti-mei-41 Antibody

price :

290 USD

immunogen :

Synthetic peptide with sequence DPHCAIEDIKVPLEQ, corresponding to the internal region of the protein sequence.

form :

Liquid

host :

Goat

contents :

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

purification :

Immunogen Affinity Purified

clonality :

Polyclonal

description :

Goat Anti-mei-41 Antibody for mei-41 detection tested with WB in Drosophila.

size :

100 ug/200 ul

reactivity :

Drosophila

applications :

gene full name :

Serine/threonine-protein kinase ATR

gene name :

mei-41

protein function :

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. Essential for the DNA damage checkpoint in larval imaginal disks and neuroblasts and for the DNA replication checkpoint in the embryo. Has also an essential role during early nuclear divisions in embryos, where it is required to delay mitosis in response to incomplete DNA replication. Also plays an important role during meiosis, where it may monitor double-strand- break repair during meiotic crossing over, to regulate the progression of prophase I, and to enforce metaphase I delay observed at the end of oogenesis.

subcellular localization :

Nucleus .

synonyms :

Serine/threonine-protein kinase ATR;2.7.11.1;Ataxia telangiectasia and Rad3-related protein homolog;ATR homolog;dATR;Meiotic protein 41;mei-41;CG4252;

tissue specificity :

Highest expression in jejunum and spleen.Lower levels found in liver and lung. No expression detected inkidney, thymus, brain or testis.

uniprot id :

Q9VXG8