Anti-Dapper homolog 1 Antibody | Boster A04683 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Dapper homolog 1 Antibody

catalog :

A04683

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

sku :

A04683

status :

Enabled

name :

Anti-Dapper homolog 1 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

DACT1

price various sizes :

25ug sample size / $99 100 ug / $299 100 ug+Free HRP Secondary BA1054 / $299 100 ug+Free Biotin Secondary BA1003 / $299

clonality :

Polyclonal

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide.

description :

Polyclonal antibody for DAPPER1/DACT1 detection. Host: Rabbit.Size: 100 ug. Tested applications: WB. Reactive species: Human. DAPPER1/DACT1 information: Molecular Weight: 90174 MW; Subcellular Localization: Cytoplasm. Nucleus. Cell junction, synapse . Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.

short description :

Rabbit IgG Polyclonal antibody for DACT1 detection. Tested with WB in Human.

size :

100 ug

sample size available :

25ug for $99, contact us for details

uniprot id :

Q9NYF0

host :

Rabbit

immunogen :

A partial length recombinant Dapper homolog 1 protein (amino acids 645-820).

form :

Liquid

storage :

Store the antibody at 4 C, stable for 6 months. For long-term storage, store at -20 C. Avoid repeated freeze and thaw cycles.

application details :

Western blot analysis, 2-4 ug/ml.

applications :

reactivity :

Human

image labels :

Western blot analysis of Dapper homolog 1. Anti-Dapper homolog 1 antibody was used at 4 ug/ml on Jurkat lysate.

competitor equivalent skus :

sc 167591 sc 167589

research category :

Cytoplasmic, Neurogenesis, Neurology Process, Neuroscience, Signaling Pathways, Stem Cells

synonyms :

Dapper homolog 1;hDPR1;Dapper antagonist of catenin 1;Hepatocellular carcinoma novel gene 3 protein;DACT1;DPR1, HNG3;

gene full name :

Dapper homolog 1

molecular weight :

90174 MW

protein function :

Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome- dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

subcellular localization :

Cytoplasm. Nucleus. Cell junction, synapse . Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.

protein name :

Dapper homolog 1

last modified :

2/6/19 22:57