Anti-SAPK interacting protein 1/Mip1 Antibody | Boster A04068 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-SAPK interacting protein 1/Mip1 Antibody

catalog :

A04068

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

sku :

A04068

status :

Enabled

name :

Anti-SAPK interacting protein 1/Mip1 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

MAPKAP1

price various sizes :

25ug sample size / $99 100 ug / $299 100 ug+Free HRP Secondary BA1054 / $299 100 ug+Free Biotin Secondary BA1003 / $299

clonality :

Polyclonal

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide.

description :

Polyclonal antibody for Sin1/MAPKAP1 detection. Host: Rabbit.Size: 100 ug. Tested applications: WB. Reactive species: Human. Sin1/MAPKAP1 information: Molecular Weight: 59123 MW; Subcellular Localization: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus; Tissue Specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle.

short description :

Rabbit IgG Polyclonal antibody for MAPKAP1 detection. Tested with WB in Human.

size :

100 ug

sample size available :

25ug for $99, contact us for details

uniprot id :

Q9BPZ7

host :

Rabbit

immunogen :

A partial length recombinant Mip1 protein (amino acids 250-522).

form :

Liquid

storage :

Store the antibody at 4 C, stable for 6 months. For long-term storage, store at -20 C. Avoid repeated freeze and thaw cycles.

application details :

Western blot analysis, 1-3 ug/ml.

applications :

reactivity :

Human

image labels :

Western blot analysis of SAPK interacting protein 1/Mip1. Anti- SAPK interacting protein 1/Mip1 antibody was used at 1 ug/ml on Hela lysate.

competitor equivalent skus :

sc 48588 sc 366259 sc 393166

research category :

Mapk Pathway, Protein Phosphorylation, Ser / Thr Kinases, Signal Transduction

synonyms :

Target of rapamycin complex 2 subunit MAPKAP1;TORC2 subunit MAPKAP1;Mitogen-activated protein kinase 2-associated protein 1;Stress-activated map kinase-interacting protein 1;SAPK-interacting protein 1;mSIN1;MAPKAP1;MIP1, SIN1;

gene full name :

Target of rapamycin complex 2 subunit MAPKAP1

molecular weight :

59123 MW

protein function :

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

subcellular localization :

Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.

tissue specificity :

Ubiquitously expressed, with highest levels in heart and skeletal muscle.

protein name :

Target of rapamycin complex 2 subunit MAPKAP1

last modified :

2/6/19 22:57