Anti-VE-Cadherin-5 CDH5 (phospho-Y731) Antibody | Boster A02632Y731 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-VE-Cadherin-5 CDH5 (phospho-Y731) Antibody

catalog :

A02632Y731

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

SKU :

A02632Y731

Product Name :

Anti-VE-Cadherin-5 CDH5 (phospho-Y731) Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, IHC

Application Details :

WB: 1:500~1:1000 IHC: 1:50~1:200

Description :

Boster Bio Anti-VE-Cadherin-5 CDH5 (phospho-Y731) Antibody catalog # A02632Y731. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Gene Name :

CDH5

Uniprot ID :

P33151

Form :

Liquid

Contents :

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Prominin-1

Synonyms :

Prominin-1; Antigen AC133; Prominin-like protein 1; CD133; PROM1; PROML1; MSTP061;

Protein Name :

Prominin-1

Molecular Weight :

97202 MW

Protein Function :

May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).

Subcellular Localization :

Apical cell membrane ; Multi- pass membrane protein. Cell projection, microvillus membrane ; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment . Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.

Tissue Specificity :

Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).