Anti-Phospho-JNK1/2/3 (Y185) MAPK8 Antibody | Boster A02608Y185-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-JNK1/2/3 (Y185) MAPK8 Antibody

catalog :

A02608Y185-1

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

SKU :

A02608Y185-1

Product Name :

Anti-Phospho-JNK1/2/3 (Y185) MAPK8 Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, IHC, ELISA

Application Details :

WB 1:500-1:2000.IHC 1:100-1:300 ELISA 1:20000

Description :

Boster Bio Anti-Phospho-JNK1/2/3 (Y185) MAPK8 Antibody catalog # A02608Y185-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1 mg/ml

Gene Name :

MAPK8

Uniprot ID :

P45983

Immunogen :

Synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Y185.

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Integrin alpha-M

Synonyms :

Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b; ITGAM; CD11B, CR3A;

Protein Name :

Integrin alpha-M

Molecular Weight :

127179 MW

Protein Function :

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).

Subcellular Localization :

Cell membrane

Tissue Specificity :

Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).