Anti-Phospho-TH (S8) Antibody | Boster A01917S8-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-TH (S8) Antibody

catalog :

A01917S8-1

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

SKU :

A01917S8-1

Product Name :

Anti-Phospho-TH (S8) Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Rat

Application(s) :

WB, IHC, ELISA

Application Details :

WB 1:500-1:2000.IHC 1:100-1:300 ELISA 1:5000

Description :

Boster Bio Anti-Phospho-TH (S8) Antibody catalog # A01917S8-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Rat.

Concentration :

1 mg/ml

Gene Name :

Uniprot ID :

P07101

Immunogen :

Synthesized peptide derived from human TH around the phosphorylation site of S8.

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Signal transducer and activator of transcription 3

Synonyms :

Signal transducer and activator of transcription 3

Protein Name :

Signal transducer and activator of transcription 3

Molecular Weight :

88068 MW

Protein Function :

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4 (+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).

Subcellular Localization :

Cytoplasm. Nucleus

Tissue Specificity :

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.