Anti-cIAP-1/HIAP-2 Antibody | Boster A01700 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-cIAP-1/HIAP-2 Antibody

catalog :

A01700

quantity :

50 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunoprecipitation

product information

sku :

A01700

status :

Enabled

name :

Anti-cIAP-1/HIAP-2 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies, IHC ICC IF Antibodies

gene name :

BIRC2

price various sizes :

50 ul / $299 50 ul+Free HRP Secondary BA1054 / $299 50 ul+Free Biotin Secondary BA1003 / $299

clonality :

Polyclonal

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

50 ul sera

description :

Polyclonal antibody for CIAP1/BIRC2 detection. Host: Rabbit.Size: 100 ug. Tested applications: IP. Reactive species: Canine. CIAP1/BIRC2 information: Molecular Weight: 69900 MW; Subcellular Localization: Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells; Tissue Specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

short description :

Rabbit IgG Polyclonal antibody for BIRC2 detection. Tested with WB, IHC, IP in Dog, Gerbil, Human, Mouse, Rat.

size :

50 ul

sample size available :

No sample size available

uniprot id :

Q13490

host :

Rabbit

immunogen :

Full-length recombinant protein of human cAIP1

form :

Liquid

storage :

Store the antibody at 4 C, stable for 6 months. For long-term storage, store at -20 C. Avoid repeated freeze and thaw cycles.

application details :

WB, 1:1000-1:2000. IHC (paraffin), 1:1000-1:5000. IHC (frozen), Users should optimize. IP, 1:50-1:200.

applications :

IP, IHC, WB

reactivity :

Canine, Human, Mouse, Rat

image labels :

Immunohistochemical analysis of cIAP1 in formalin-fixed, paraffin-embedded human prostate using primary antibody dilution ratio of 1:2000. A, normal prostate. B, prostate intraepithelial neoplasia (PIN). PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-eosin counterstain. Increased cIAP1 expression is PIN and in prostate cancer compared to normal prostate. Western blot analysis of cIAP1 in human prostate using primary antibody dilution ratio of 1:1000. PBH (benign prostate hyperplasia), PIN (prostate intraepithelial neoplasia). Elevated levels of cIAP1 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.

competitor equivalent skus :

sc 5944 sc 5945 sc 5947 sc 367803 sc 5944 X sc 5945 X sc 367803 X sc 5947 X

research category :

Apoptosis, Apoptotic Markers, Cancer, Cancer Metabolism, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways And Processes, Receptors, Response To Hypoxia

synonyms :

Baculoviral IAP repeat-containing protein 2;6.3.2.-;Cellular inhibitor of apoptosis 1;C-IAP1 ;IAP homolog B;Inhibitor of apoptosis protein 2;hIAP-2;hIAP2;RING finger protein 48;TNFR2-TRAF-signaling complex protein 2;BIRC2;API1, MIHB, RNF48;

gene full name :

Baculoviral IAP repeat-containing protein 2

molecular weight :

69900 MW

protein function :

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

subcellular localization :

Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

tissue specificity :

Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

protein name :

Baculoviral IAP repeat-containing protein 2

last modified :

2/6/19 22:57