Anti-Human IDE DyLight® 550 conjugated Antibody | Boster A01358-Dyl550 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Human IDE DyLight® 550 conjugated Antibody

catalog :

A01358-Dyl550

quantity :

50 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

DyLight 550

reactivity :

human

application :

flow cytometry

product information

SKU :

A01358-Dyl550

Product Name :

Anti-Human IDE DyLight® 550 conjugated Antibody

Size :

50 ug/vial

Clonality :

Polyclonal

Host :

Rabbit

Conjugate :

DyLight®550

Reactivity :

Human

Application(s) :

Flow Cytometry

Application Details :

Flow Cytometry, 1-3μg/1x10^6 cells

Description :

Boster Bio Anti-Human IDE DyLight® 550 conjugated Antibody catalog # A01358-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

IDE

Uniprot ID :

P14735

Immunogen :

E. coli-derived human IDE recombinant protein (Position: F485-K756).

Form :

Liquid

Contents :

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Cross-reactivity :

No cross reactivity with other proteins.

Storage :

At 2-8?C for one year from date of receipt. Protect from light. Do not freeze.

Gene Full Name :

insulin degrading enzyme

Synonyms :

Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin; IDE

Protein Function :

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Subcellular Localization :

Cytoplasm. Cell membrane. Secreted. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Background :

Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Research Category :

Alzheimer'S Disease, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Diabetes, Diabetes Associated, Growth Factors/Hormones, Heart Disease, Metabolism, Metalloprotease, Neurodegenerative Disease, Neurology Process, Neuroscience, Proteolysis / Ubiquitin, Proteolytic Enzymes, Signal Transduction