Anti-keratin 18 Antibody | Boster A01357 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-keratin 18 Antibody

catalog :

A01357

quantity :

100 ug/200 ul

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

A01357

name :

Anti-keratin 18 Antibody

price :

290 USD

immunogen :

Synthetic peptide with sequence C-EELDKYWSQQIE, corresponding to the internal region of the protein sequence.

form :

Liquid

host :

Goat

contents :

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

purification :

Immunogen Affinity Purified

clonality :

Polyclonal

description :

Goat Anti-keratin 18 Antibody for KRT18 detection tested with WB in Human, Mouse, Rat, Dog, Pig, Cow.

size :

100 ug/200 ul

reactivity :

Human; Mouse; Rat

applications :

background :

Intermediate filaments(IFs) are a structurally related family of cellular proteins that appear to be intimately involved with the cytoskeleton. Human keratin 18(KRT18) and the homologous mouse Endo B are type I IF protein subunits whose expression is restricted in adults to a variety of simple epithelial tissues. The KRT18 gene is 3,791 bp long and the keratin 18 protein is coded for by 7 exons. The K18 gene is 3791 bp in length and the K18 protein is coded for by seven exons. By Southern blotting using the genomic DNA PCR product, the gene for keratin 18 is assigned to chromosome 12. Mutation of human keratin 18 in association with cryptogenic cirrhosis.

gene full name :

Keratin, type I cytoskeletal 18

gene name :

KRT18

predicted reactivity :

Bovine

protein function :

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

research category :

signal transduction cytoskeleton / ecm extracellular matrix ecm proteins cytokeratin signal transduction structures cytoskeleton intermediate filaments class i microtubules

subcellular localization :

Cytoplasm, perinuclear region. Nucleus, nucleolus.

synonyms :

Keratin, type I cytoskeletal 18;Cell proliferation-inducing gene 46 protein;Cytokeratin-18;CK-18;Keratin-18;K18;KRT18;CYK18;PIG46;

tissue specificity :

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

uniprot id :

P05783