Anti-c-Kit Antibody | Boster A01335 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-c-Kit Antibody

catalog :

A01335

quantity :

100 ul

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

product information

sku :

A01335

name :

Anti-c-Kit Antibody

price :

200 USD

immunogen :

Synthesized peptide derived from human c-Kit around the non-phosphorylation site of Y936.

form :

Liquid

host :

Rabbit

contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

purification :

Immunogen affinity purified

clonality :

Polyclonal

description :

Rabbit Polyclonal Antibody for c-Kit Antibody (KIT) detection. Tested with WB, IHC in Human, Mouse.

size :

100 ul

reactivity :

Human; Mouse

applications :

IHC; WB

gene full name :

Mast/stem cell growth factor receptor Kit

gene name :

KIT

protein function :

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

research category :

immunology cell type markers cytokines tags & cell markers tumor associated signal transduction protein phosphorylation tyrosine kinases receptor tyrosine kinases neuroscience neurotransmission receptors / channels tyrosine kinase receptors stem cells germline stem cells embryonic germ cells hematopoietic progenitors surface molecules cancer oncoproteins/suppressors oncoproteins growth factor receptors myeloid mast cell lineage hematopoietic stem cells hsc markers developmental biology reproduction germ cell markers organogenesis hematopoietic system development

storage :

Store at -20 for one year, at 4 for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20℃ upon receiving. Avoid repeated freezing and thawing.

subcellular localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

synonyms :

Mast/stem cell growth factor receptor Kit;SCFR;2.7.10.1;Piebald trait protein;PBT;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;p145 c-kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;CD117;KIT;SCFR;

tissue specificity :

Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells.

uniprot id :

P10721