Anti-HSP 90 K294 Antibody | Boster A01103 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-HSP 90 K294 Antibody

catalog :

A01103

quantity :

100 ug

price :

339 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

sku :

A01103

name :

Anti-HSP 90 K294 Antibody

price :

339 USD

form :

Liquid

host :

Rabbit

clonality :

Polyclonal

description :

Anti-HSP 90 K294 Antibody validated for WB in Human.

size :

100 ug

reactivity :

Human; Mouse; Rat

applications :

IHC; WB

background :

Heat shock protein HSP 90-alpha??is a??protein??that in humans is encoded by the??HSP90AA1??gene. The gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A). Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress. Once expressed Hsp90A dimers operate as molecular chaperones that bind and fold other proteins into their functional 3-dimensional structures. This molecular chaperoning ability of Hsp90A is driven by a cycle of structural rearrangements fueled by ATP hydrolysis. Current research on Hsp90A focuses in its role as a drug target due to its interaction with a large number of tumor promoting proteins and its role in cellular stress adaptation.

concentration :

0.96 mg/mL by UV absorbance at 280 nm

gene full name :

Heat shock protein HSP 90-alpha

gene name :

HSP90AA1

protein function :

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

research category :

signal transduction protein trafficking chaperones heat shock proteins cancer tumor biomarkers

subcellular localization :

Cytoplasm. Melanosome. Cell membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

synonyms :

Heat shock protein HSP 90-alpha;Heat shock 86 kDa;HSP 86;HSP86;Lipopolysaccharide-associated protein 2;LAP-2;LPS-associated protein 2;Renal carcinoma antigen NY-REN-38;HSP90AA1;HSP90A, HSPC1, HSPCA;

uniprot id :

P07900