Anti-Myelin Protein Zero/MPZ Antibody Picoband™ | Boster A00997-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Myelin Protein Zero/MPZ Antibody Picoband™

catalog :

A00997-1

quantity :

100µg/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA

product information

SKU :

A00997-1

Product Name :

Anti-Myelin Protein Zero/MPZ Antibody Picoband™

Size :

100µg/vial

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, ELISA

Application Details :

Western blot, 0.1-0.5µg/ml. Direct ELISA, 0.1-0.5µg/ml.

Description :

Boster Bio Anti-Myelin Protein Zero/MPZ Antibody Picoband™ catalog # A00997-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

MPZ

Uniprot ID :

P25189

Immunogen :

E. coli-derived human Myelin Protein Zero recombinant protein (Position: I30-R153).

Form :

Lyophilized

Contents :

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg NaN 3 .

Cross-reactivity :

No cross reactivity with other proteins.

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Gene Full Name :

myelin protein zero

Synonyms :

Myelin protein P0; Myelin peripheral protein; MPP; Myelin protein zero; MPZ

Protein Function :

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein. Cell membrane.

Tissue Specificity :

Found only in peripheral nervous system Schwann cells.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Background :

Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the MPZ gene. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

Research Category :

Protein Phosphorylation, Signal Transduction, Tyrosine Phosphatases