Anti-Flk-1 Antibody | Boster A00901 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Flk-1 Antibody

catalog :

A00901

quantity :

100 ul

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry

product information

sku :

A00901

name :

Anti-Flk-1 Antibody

price :

200 USD

immunogen :

Synthesized peptide derived from human Flk-1 around the non-phosphorylation site of Y1214.

form :

Liquid

host :

Rabbit

contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

purification :

Immunogen affinity purified

clonality :

Polyclonal

description :

Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection. Tested with WB, IHC, IF in Human, Mouse, Rat.

size :

100 ul

reactivity :

Rat

applications :

IF; IHC; WB

gene full name :

Vascular endothelial growth factor receptor 2

gene name :

KDR

protein function :

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

research category :

cardiovascular angiogenesis growth factors vegf vegf receptors microbiology interspecies interaction host virus interaction signal transduction protein phosphorylation tyrosine kinases receptor tyrosine kinases growth factors/hormones stem cells hematopoietic progenitors surface molecules cancer invasion/microenvironment angiogenic growth factors oncoproteins/suppressors oncoproteins growth factor receptors endothelial progenitors endothelial markers cancer metabolism response to hypoxia cardiovascular cardiovascular markers cell markers endothelial cells metabolism pathways and processes metabolism processes

storage :

Store at -20 for one year, at 4 for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20℃ upon receiving. Avoid repeated freezing and thawing.

subcellular localization :

Cell junction . Endoplasmic reticulum . Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610).

synonyms :

Vascular endothelial growth factor receptor 2;VEGFR-2;2.7.10.1;Fetal liver kinase 1;FLK-1;Kinase insert domain receptor;KDR;Protein-tyrosine kinase receptor flk-1;CD309;KDR;FLK1, VEGFR2;

tissue specificity :

Detected in cornea (at protein level). Widely expressed.

uniprot id :

P35968