Anti-Ang-1 (E207) ANGPT1 Antibody | Boster A00853-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Ang-1 (E207) ANGPT1 Antibody

catalog :

A00853-1

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

SKU :

A00853-1

Product Name :

Anti-Ang-1 (E207) ANGPT1 Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, IHC

Application Details :

WB: 1:500~1:1000 IHC: 1:50~1:200

Description :

Boster Bio Anti-Ang-1 (E207) ANGPT1 Antibody catalog # A00853-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Gene Name :

ANGPT1

Uniprot ID :

Q15389

Form :

Liquid

Contents :

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Programmed cell death 1 ligand 1

Synonyms :

Programmed cell death 1 ligand 1

Protein Name :

Programmed cell death 1 ligand 1

Molecular Weight :

33275 MW

Protein Function :

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).

Subcellular Localization :

Cell membrane

Tissue Specificity :

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.