Anti-EPO Antibody Picoband™ | Boster A00484-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-EPO Antibody Picoband™

catalog :

A00484-1

quantity :

100µg/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, ELISA

product information

SKU :

A00484-1

Product Name :

Anti-EPO Antibody Picoband™

Size :

100µg/vial

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Mouse, Rat

Application(s) :

WB, ELISA

Application Details :

Western blot, 0.1-0.5µg/ml. ELISA (Cap), 1-5µg/ml.

Description :

Boster Bio Anti-EPO Antibody Picoband™ catalog # A00484-1. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

Epo

Uniprot ID :

P07321

Immunogen :

E. coli-derived mouse EPO recombinant protein (Position: D34-R192).

Form :

Lyophilized

Contents :

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg NaN 3 .

Cross-reactivity :

No cross reactivity with other proteins.

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Gene Full Name :

erythropoietin

Synonyms :

Erythropoietin; Epo

Protein Function :

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.

Subcellular Localization :

Secreted.

Tissue Specificity :

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Background :

This EPO gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies.

Research Category :

Angiogenesis, Apoptosis, Atherosclerosis, Cardiovascular, G Protein Signaling, Hematopoietic Progenitors, Hypertrophy, Immunoglobulins, Immunology, Receptors, Signal Transduction, Signaling Pathway, Small G Proteins, Stem Cells, Surface Molecules