Anti-Survivin BIRC5 Antibody | Boster A00379-2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Survivin BIRC5 Antibody

catalog :

A00379-2

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

product information

SKU :

A00379-2

Product Name :

Anti-Survivin BIRC5 Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human

Application(s) :

WB, ICC, IF, IHC, Flow Cytometry

Application Details :

WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Description :

Boster Bio Anti-Survivin BIRC5 Antibody catalog # A00379-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human.

Gene Name :

BIRC5

Uniprot ID :

O15392

Form :

Liquid

Contents :

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification :

ProA affinity purified

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

C-C motif chemokine 5

Synonyms :

C-C motif chemokine 5; EoCP; Eosinophil chemotactic cytokine; SIS-delta; Small-inducible cytokine A5; T cell-specific protein P228; TCP228; T-cell-specific protein RANTES; RANTES (3-68); RANTES (4-68); CCL5; D17S136E, SCYA5;

Protein Name :

C-C motif chemokine 5

Molecular Weight :

9990 MW

Protein Function :

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES (3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1- infection. The second processed form RANTES (4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES (1- 68) and RANTES (3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.