Anti-Survivin BIRC5 Antibody | Boster A00379-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Survivin BIRC5 Antibody

catalog :

A00379-1

quantity :

0.1 mg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

SKU :

A00379-1

Product Name :

Anti-Survivin BIRC5 Antibody

Size :

0.1 mg

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse

Application(s) :

ELISA, WB, ICC, IHC, IF

Application Details :

Survivin antibody can be used for detection of survivin by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL and immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Application Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Survivin BIRC5 Antibody catalog # A00379-1. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse.

Concentration :

1 mg/mL

Gene Name :

BIRC5

Uniprot ID :

O15392

Immunogen :

Survivin antibody was raised against a peptide corresponding to 12 amino acids near the amino terminus of human survivin. The immunogen is located within the first 50 amino acids of Survivin.

Form :

Liquid

Contents :

Survivin Antibody is supplied in PBS containing 0.02% sodium azide.

Purification :

Survivin Antibody is affinity chromatography purified via peptide column.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

cyclin dependent kinase inhibitor 1C

Synonyms :

Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2; CDKN1C; KIP2

Protein Function :

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Subcellular Localization :

Nucleus.

Tissue Specificity :

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Background :

Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. It is mapped to 11p15.4. This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.