Anti-RANK-L TNFSF11 Antibody | Boster A00363 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-RANK-L TNFSF11 Antibody

catalog :

A00363

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot

product information

SKU :

A00363

Product Name :

Anti-RANK-L TNFSF11 Antibody

Size :

100 ug

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Application Details :

Western Blot, 1:1000, mouse, rat

Description :

Boster Bio Anti-RANK-L TNFSF11 Antibody catalog # A00363. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1.0 mg/mL by UV absorbance at 280 nm

Gene Name :

TNFSF11

Uniprot ID :

O14788

Immunogen :

Anti-sRANK-L antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the internal region of human sRANK-L.

Form :

Lyophilized

Contents :

0.01 M Sodium Phosphate. 0.25 M Sodium Chloride. pH 7.2. 0.02% (w/v) Sodium Azide

Purification :

Immunoaffinity purified

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Tumor necrosis factor ligand superfamily member 11

Synonyms :

Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD254; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; TNFSF11; OPGL, RANKL, TRANCE;

Molecular Weight :

35478 MW

Protein Function :

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type II membrane protein.

Tissue Specificity :

Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

Background :

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This gene is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Research Category :

Cytoskeleton / Ecm, Extracellular Matrix, Immunology, Innate Immunity, Signal Transduction, Structures, Tnf Superfamily