Anti-Granzyme B GZMB Antibody | Boster A00353 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Granzyme B GZMB Antibody

catalog :

A00353

quantity :

100µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry

product information

SKU :

A00353

Product Name :

Anti-Granzyme B GZMB Antibody

Size :

100µl

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, IHC

Application Details :

WB, 1:500-1:3000.IHC, 1:50-1:100.

Description :

Boster Bio Anti-Granzyme B GZMB Antibody catalog # A00353. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

GZMB

Uniprot ID :

P10144

Immunogen :

Synthesized peptide derived from human Granzyme B.

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification :

Immunogen affinity purified

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Granzyme B

Synonyms :

Granzyme B; 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMB; CGL1, CSPB, CTLA1, GRB;

Molecular Weight :

27716 MW

Protein Function :

This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Subcellular Localization :

Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Research Category :

Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, Nk Cells, T Cells