Anti-RET Antibody | Boster A00293 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-RET Antibody

catalog :

A00293

quantity :

100 ul

price :

269 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

product information

sku :

A00293

name :

Anti-RET Antibody

price :

269 USD

immunogen :

KLH conjugated synthetic peptide derived from human RET 998-1030 amino acid.

form :

Liquid

host :

Rabbit

contents :

Buffered solution contains 1% BSA, 50% glycerol and 0.09% sodium azide.

purification :

Protein A Purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Proto-oncogene tyrosine-protein kinase receptor Ret (RET) detection. Tested with WB, IHC-P, IF in Human, Mouse, Rat.

size :

100 ul

reactivity :

Human; Mouse; Rat

applications :

IF; IHC-P; WB

gene full name :

Proto-oncogene tyrosine-protein kinase receptor Ret

gene name :

RET

protein function :

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.

research category :

signal transduction protein phosphorylation tyrosine kinases receptor tyrosine kinases cancer oncoproteins/suppressors oncoproteins growth factor receptors

storage :

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein .

synonyms :

Proto-oncogene tyrosine-protein kinase receptor Ret;2.7.10.1;Cadherin family member 12;Proto-oncogene c-Ret;Soluble RET kinase fragment;Extracellular cell-membrane anchored RET cadherin 120 kDa fragment;RET;CDHF12, CDHR16, PTC, RET51;

uniprot id :

P07949