Anti-TNAP3 Antibody | Boster A00224 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-TNAP3 Antibody

catalog :

A00224

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

product information

sku :

A00224

status :

Enabled

name :

Anti-TNAP3 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies, IHC ICC IF Antibodies

gene name :

TNFAIP3

price various sizes :

5ul sample size / $40 100ul / $299 100ul+Free HRP Secondary BA1054 / $299 100ul+Free Biotin Secondary BA1003 / $299

clonality :

Polyclonal

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

description :

Polyclonal antibody for A20/TNFAIP3 detection. Host: Rabbit.Size: 100ul. Tested applications: IF. Reactive species: Human. A20/TNFAIP3 information: Molecular Weight: 89614 MW; Subcellular Localization: Cytoplasm. Nucleus. Lysosome.

short description :

Rabbit Polyclonal Antibody for TNAP3 (TNFAIP3) detection.tested for IF, IHC, WB in Human, Mouse.

size :

100 ul

sample size available :

5ul, free with shipping charge

uniprot id :

P21580

host :

Rabbit

immunogen :

Synthesized peptide derived from internal of human TNAP3.

form :

Liquid

purification :

Immunogen affinity purified

storage :

Store at -20 C for one year, at 4 C for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20 C upon receiving. Avoid repeated freezing and thawing.

application details :

WB, 1:500-1:3000. Immunofluorescence, 1:100-1:500

applications :

IF, WB

reactivity :

Human, Mouse

image labels :

Western blot analysis of extracts from RAW264.7 cells, using TNAP3 antibody A00224. Immunofluorescence analysis of HepG2 cells, using TNAP3 antibody A00224.

competitor equivalent skus :

sc 17856 sc 22834 sc 166692 sc 32524 sc 32523 sc 376564 sc 32525 sc 32797 sc 52910 sc 69980 sc 17856 X sc 32524 X sc 22834 X sc 32523 X sc 376564 X sc 32525 X sc 166692 X sc 32797 X

research category :

Epigenetics And Nuclear Signaling, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tnf Superfamily, Ubiquitin & Ubiquitin Like Modifiers

synonyms :

Tumor necrosis factor alpha-induced protein 3;TNF alpha-induced protein 3;3.4.19.12;6.3.2.-;OTU domain-containing protein 7C;Putative DNA-binding protein A20;Zinc finger protein A20;A20p50;A20p37;TNFAIP3;OTUD7C;

gene full name :

Tumor necrosis factor alpha-induced protein 3

molecular weight :

89614 MW

protein function :

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS- induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.

subcellular localization :

Cytoplasm. Nucleus. Lysosome.

last modified :

2/6/19 22:57