Anti-TET2 Antibody | Boster A00191 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-TET2 Antibody

catalog :

A00191

quantity :

100 ug/200 ul

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunohistochemistry

product information

sku :

A00191

name :

Anti-TET2 Antibody

price :

290 USD

immunogen :

Synthetic peptide with sequence C-PHPQSNNDQQREGSF, corresponding to the internal region of the protein sequence.

form :

Liquid

host :

Goat

contents :

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

purification :

Immunogen Affinity Purified

clonality :

Polyclonal

description :

Goat Anti-TET2 Antibody for TET2 detection tested with IHC in Human, Mouse, Dog.

size :

100 ug/200 ul

reactivity :

Human; Mouse

applications :

IHC

concentration :

72.50 mg/mL by Refractometry

gene full name :

Methylcytosine dioxygenase TET2

gene name :

TET2

predicted reactivity :

Canine

protein function :

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

research category :

epigenetics and nuclear signaling dna methylation methylated dna associated

storage :

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time. Avoid repeated freezing and thawing.

synonyms :

Methylcytosine dioxygenase TET2;1.14.11.n2;TET2;KIAA1546;Nbla00191;

tissue specificity :

Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.

uniprot id :

Q6N021