Anti-Dicer1 Antibody | Boster A00190 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Dicer1 Antibody

catalog :

A00190

quantity :

100 ug/200 ul

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry

product information

sku :

A00190

name :

Anti-Dicer1 Antibody

price :

290 USD

immunogen :

Synthetic peptide with sequence QDKSNTDKWEKDEMTKDC, corresponding to the internal region of the protein sequence.

form :

Liquid

host :

Goat

contents :

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

purification :

Immunogen Affinity Purified

clonality :

Polyclonal

description :

Goat Anti-Dicer1 Antibody for DICER1 detection tested with IHC in Human, Mouse, Rat, Dog, Pig, Cow.

size :

100 ug/200 ul

reactivity :

Human; Mouse; Rat

applications :

IHC

background :

Dicer(DICER1), also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. It is mapped to 14q32.13. The DICER1 gene, a member of the ribonuclease III (RNaseIII) family, is involved in the generation of microRNAs (miRNAs), which modulate gene expression at the posttranscriptional level. DICER1 possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus DICER, also known as helicase-MOI, is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. In addition, DICER1 is required for formation of the RNA induced silencing complex (RISC). It also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.

concentration :

0.5 mg/mL

gene full name :

Endoribonuclease Dicer

gene name :

Dicer1

predicted reactivity :

Bovine; Canine; Pig

protein function :

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).

research category :

epigenetics and nuclear signaling dna / rna rna processing rnai epigenetics and nuclear signaling dicer nuclear signaling pathways nuclear receptors nuclear pore complex

storage :

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time. Avoid repeated freezing and thawing.

subcellular localization :

cytoplasm

synonyms :

Endoribonuclease Dicer;3.1.26.3;Double-strand-specific ribonuclease mDCR-1;Dicer1;Dicer, Mdcr;

tissue specificity :

Isoform 1 is expressed in a wide variety of tissues. Isoform 2 is specifically expressed in oocytes during their growth (at protein level).

uniprot id :

Q8R418