Anti-FLT3(Ab-591) Antibody | Boster A00188 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-FLT3(Ab-591) Antibody

catalog :

A00188

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry

product information

sku :

A00188

status :

Enabled

name :

Anti-FLT3(Ab-591) Antibody

category name :

Primary Antibodies, Polyclonal Antibodies, IHC ICC IF Antibodies

gene name :

FLT3

price various sizes :

5ul sample size / $40 100ul / $299 100ul+Free HRP Secondary BA1054 / $299 100ul+Free Biotin Secondary BA1003 / $299

clonality :

Polyclonal

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

description :

Polyclonal antibody for CD135/FLT3 detection. Host: Rabbit.Size: 100ul. Tested applications: IF. Reactive species: Human. CD135/FLT3 information: Molecular Weight: 112903 MW; Subcellular Localization: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation; Tissue Specificity: Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.

short description :

Rabbit Polyclonal Antibody for FLT3(Ab-591) (FLT3) detection.tested for IF, IHC, WB in Human.

size :

100 ul

sample size available :

5ul, free with shipping charge

uniprot id :

P36888

host :

Rabbit

immunogen :

Peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3.

form :

Liquid

purification :

Immunogen affinity purified

storage :

Store at -20 C for one year, at 4 C for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20 C upon receiving. Avoid repeated freezing and thawing.

application details :

WB, 1:500-1:1000. Immunofluorescence, 1:100-1:200

applications :

IF, WB

reactivity :

Human

image labels :

Western blot analysis of extracts from 293 and MCF cells using FLT3(Ab-591) antibody A00188. Immunofluorescence staining of methanol-fixed Hela cells using FLT3(Ab-591) antibody A00188.

competitor equivalent skus :

sc 20733 sc 19635 sc 480 sc 479 sc 21788 sc 101343 sc 340

research category :

Angiogenesis, Cardiovascular, Cytokines, Immunology, Innate Immunity

synonyms :

Receptor-type tyrosine-protein kinase FLT3;2.7.10.1;FL cytokine receptor;Fetal liver kinase-2;FLK-2;Fms-like tyrosine kinase 3;FLT-3;Stem cell tyrosine kinase 1;STK-1;CD135;FLT3;CD135, FLK2, STK1;

gene full name :

Receptor-type tyrosine-protein kinase FLT3

molecular weight :

112903 MW

protein function :

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

subcellular localization :

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.

tissue specificity :

Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.

last modified :

2/6/19 22:57