Anti-DNMT1 Antibody | Boster A00172 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-DNMT1 Antibody

catalog :

A00172

quantity :

100 ug/200 ul

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

sku :

A00172

name :

Anti-DNMT1 Antibody

price :

290 USD

immunogen :

Synthetic peptide with sequence C-RFESPPKTQPTEDN, corresponding to the internal egion of the protein sequence.

form :

Liquid

host :

Goat

contents :

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

purification :

Immunogen Affinity Purified

clonality :

Polyclonal

description :

Goat Anti-DNMT1 Antibody for DNMT1 detection tested with WB, IHC in Human, Mouse, Rat, Dog, Cow, Pig.

size :

100 ug/200 ul

reactivity :

Human; Mouse; Rat

applications :

IHC; WB

background :

DNMT1 preferentially methylates CpG residues in hemimethylated DNA and is responsible for maintaining methylation patterns established in development. Inactivation of DNMT1 causes global demethylation and embryonic lethality. DNA methylation is coordinated with methylation of histones. Transcriptional repression by DNMT1 is mediated by direct interaction with HDAC2.

gene full name :

DNA (cytosine-5)-methyltransferase 1

gene name :

DNMT1

predicted reactivity :

Bovine; Canine; Pig

protein function :

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

research category :

epigenetics and nuclear signaling dna methylation dnmts epigenetics and nuclear signaling chip'ing antibodies

subcellular localization :

Nucleus .

synonyms :

DNA (cytosine-5)-methyltransferase 1;Dnmt1;2.1.1.37;CXXC-type zinc finger protein 9;DNA methyltransferase HsaI;DNA MTase HsaI;M.HsaI;MCMT;DNMT1;AIM, CXXC9, DNMT;

tissue specificity :

Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.

uniprot id :

P26358