Anti-Phospho-ICAM-1 (Y512) Antibody | Boster A00171Y512-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-ICAM-1 (Y512) Antibody

catalog :

A00171Y512-1

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA

product information

SKU :

A00171Y512-1

Product Name :

Anti-Phospho-ICAM-1 (Y512) Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human

Application(s) :

WB, ELISA

Application Details :

WB 1:500-1:2000 ELISA 1:40000

Description :

Boster Bio Anti-Phospho-ICAM-1 (Y512) Antibody catalog # A00171Y512-1. Tested in ELISA, WB applications. This antibody reacts with Human.

Concentration :

1 mg/ml

Gene Name :

ICAM1

Uniprot ID :

P05362

Immunogen :

Synthesized peptide derived from human ICAM-1 around the phosphorylation site of Y512.

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Neutrophil gelatinase-associated lipocalin

Synonyms :

Neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; LCN2; HNL, NGAL;

Protein Name :

Neutrophil gelatinase-associated lipocalin

Molecular Weight :

22588 MW

Protein Function :

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Subcellular Localization :

Secreted

Tissue Specificity :

Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.