Anti-Cardif Antibody | Boster A00169 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Cardif Antibody

catalog :

A00169

quantity :

100 ug/vial

price :

371 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

product information

sku :

A00169

name :

Anti-Cardif Antibody

price :

371 USD

immunogen :

Recombinant human Cardif (CARD adapter inducing interferon-beta ) (aa 160-450).

form :

Liquid

host :

Rabbit

contents :

Each vial contains 0.02% sodium azide.

purification :

Protein A-affinity purified.

clonality :

Polyclonal

description :

Rabbit Anti-Cardif Antibody for MAVS detection tested with ICC, IP, WB in Human.

size :

100 ug/vial

reactivity :

Human

applications :

IP; ICC; WB

concentration :

1 mg/mL

gene full name :

Mitochondrial antiviral-signaling protein

gene name :

MAVS

protein function :

Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.

protein name :

Mitochondrial antiviral-signaling protein (MAVS)

research category :

signal transduction signaling pathway nuclear signaling nfkb pathway epigenetics and nuclear signaling nuclear signaling pathways immunology immune system diseases antiviral signaling chip'ing antibodies

storage :

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time. Avoid repeated freezing and thawing.

subcellular localization :

Mitochondrion outer membrane. Mitochondrion. Peroxisome.

synonyms :

Mitochondrial antiviral-signaling protein;MAVS;CARD adapter inducing interferon beta;Cardif;Interferon beta promoter stimulator protein 1;IPS-1;Putative NF-kappa-B-activating protein 031N;Virus-induced-signaling adapter;VISA;MAVS;IPS1, KIAA1271, VISA;

tissue specificity :

Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.

uniprot id :

Q7Z434