Anti-IRF3 (Ser396) Antibody | Boster A00165 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-IRF3 (Ser396) Antibody

catalog :

A00165

quantity :

100 ul

price :

299.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

product information

sku :

A00165

name :

Anti-IRF3 (Ser396) Antibody

price :

299.5 USD

immunogen :

KLH conjugated synthetic phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396 375-425 amino acid.

form :

Liquid

host :

Rabbit

contents :

Buffered solution contains 1% BSA, 50% glycerol and 0.09% sodium azide.

purification :

Protein A Purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Interferon regulatory factor 3 (IRF3) detection. Tested with WB, IHC-P, IF in Human, Mouse, Rat.

size :

100 ul

reactivity :

Human; Mouse; Rat

applications :

IF; IHC-P; WB

gene full name :

Interferon regulatory factor 3

gene name :

IRF3

protein function :

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

research category :

immunology innate immunity cytokines interferons epigenetics and nuclear signaling transcription other factors immunology tlr signaling

storage :

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Cytoplasm . Nucleus . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

synonyms :

Interferon regulatory factor 3;IRF-3;IRF3;

tissue specificity :

Expressed constitutively in a variety of tissues.

uniprot id :

Q14653