Anti-Cdk4 Antibody | Boster A00159 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Cdk4 Antibody

catalog :

A00159

quantity :

100 uL

price :

329 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

product information

sku :

A00159

name :

Anti-Cdk4 Antibody

price :

329 USD

form :

Liquid

host :

Rabbit

clonality :

Polyclonal

description :

Anti-Cdk4 Antibody validated for WB in Human.

size :

100 uL

reactivity :

Human

applications :

IP; WB

background :

Cyclin-dependent kinase-4(CDK4) is a protein-serine kinase involved in the cell cycle. Human cell division is regulated primarily at the G1-to-S or the G2-to-M boundaries within the cell cycle. The complexes formed by CDK4 and the D-type cyclins are involved in the control of cell proliferation during the G1 phase. CDK4 is inhibited by p16, also known as cyclin-dependent kinase inhibitor-2. CDK4 is mapped to 12q14. CDK4 expression and activity are required for cytokine responsiveness in T cells.

concentration :

85 mg/mL by Refractometry

cross reactivity :

No cross reactivity with other proteins.

gene full name :

Cyclin-dependent kinase 4

gene name :

CDK4

protein function :

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

research category :

cell biology cell cycle kinases/phosphatases cdks epigenetics and nuclear signaling cancer isotype/loading controls cdk4

subcellular localization :

Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.

synonyms :

Cyclin-dependent kinase 4;2.7.11.22;Cell division protein kinase 4;PSK-J3;CDK4;

uniprot id :

P11802