Anti-Matrix metalloproteinase-9 MMP9 Antibody | Boster A00139 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Matrix metalloproteinase-9 MMP9 Antibody

catalog :

A00139

quantity :

0.1 mg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

SKU :

A00139

Product Name :

Anti-Matrix metalloproteinase-9 MMP9 Antibody

Size :

0.1 mg

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

ELISA, WB, IHC, IF

Application Details :

MMP9 antibody can be used for detection of MMP9 by Western blot at 1 - 2 µg/ml. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Application Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Matrix metalloproteinase-9 MMP9 Antibody catalog # A00139. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1 mg/mL

Gene Name :

MMP9

Uniprot ID :

P14780

Immunogen :

MMP9 antibody was raised against a 16 amino acid peptide near the center of human MMP9. The immunogen is located within amino acids 260 - 310 of MMP9 .

Form :

Liquid

Contents :

MMP9 Antibody is supplied in PBS containing 0.02% sodium azide.

Purification :

MMP9 Antibody is affinity chromatography purified via peptide column.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

hepatocyte growth factor-regulated tyrosine kinase substrate

Synonyms :

Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110; HGS; HRS

Protein Function :

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Subcellular Localization :

Early endosome membrane. Peripheral membrane protein. Cytoplasmic side. Multivesicular body membrane. Cytoplasm.

Tissue Specificity :

Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P) and ICC.

Background :

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene. It is mapped to 17q25.3. The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.