Anti-PARP1 (N-term ZF1) Antibody | Boster A00122 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-PARP1 (N-term ZF1) Antibody

catalog :

A00122

quantity :

100 uL

price :

339 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

sku :

A00122

name :

Anti-PARP1 (N-term ZF1) Antibody

price :

339 USD

form :

Liquid

host :

Rabbit

clonality :

Polyclonal

description :

Anti-PARP1 (N-term ZF1) Antibody validated for WB in Human.

size :

100 uL

reactivity :

Human

applications :

background :

Poly[ADP-ribose] polymerase 1(PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

concentration :

1.0 mg/ml by UV absorbance at 280 nm

gene full name :

Poly [ADP-ribose] polymerase 1

gene name :

PARP1

protein function :

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

research category :

epigenetics and nuclear signaling chromatin modifying enzymes adp-ribosylation

subcellular localization :

Nucleus. Nucleus, nucleolus. Localizes at sites of DNA damage.

synonyms :

Poly [ADP-ribose] polymerase 1;PARP-1;2.4.2.30;ADP-ribosyltransferase diphtheria toxin-like 1;ARTD1;NAD(+) ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1;PARP1;ADPRT, PPOL;

uniprot id :

P09874