Anti-BCL2 Antibody | Boster A00040 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-BCL2 Antibody

catalog :

A00040

quantity :

100 ug/200 ul

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

A00040

name :

Anti-BCL2 Antibody

price :

290 USD

immunogen :

Synthetic peptide with sequence AGRTGYDNREIVMKYC, corresponding to the N Terminus of the protein sequence.

form :

Liquid

host :

Goat

contents :

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

purification :

Immunogen Affinity Purified

clonality :

Polyclonal

description :

Goat Anti-BCL2 Antibody for BCL2 detection tested with WB in Human, Mouse, Rat, Dog.

size :

100 ug/200 ul

reactivity :

Human; Mouse; Rat

applications :

background :

Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t(14;18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line.

gene full name :

Apoptosis regulator Bcl-2

gene name :

BCL2

predicted reactivity :

Canine

protein function :

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

subcellular localization :

Mitochondrion outer membrane ; Single-pass membrane protein . Nucleus membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .

synonyms :

Apoptosis regulator Bcl-2;BCL2;

tissue specificity :

Expressed in a variety of tissues.

uniprot id :

P10415