Anti-P105 RB Antibody | Boster A00039 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-P105 RB Antibody

catalog :

A00039

quantity :

100 ul

price :

279.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

product information

sku :

A00039

name :

Anti-P105 RB Antibody

price :

279.5 USD

immunogen :

KLH conjugated synthetic peptide derived from human Rb/P105 RB 68-116 amino acid.

form :

Liquid

host :

Rabbit

contents :

Buffered solution contains 1% BSA, 50% glycerol and 0.09% sodium azide.

purification :

Protein A Purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Retinoblastoma-associated protein (RB1) detection. Tested with WB, IHC-P, IF in Human, Mouse, Rat.

size :

100 ul

reactivity :

Human; Mouse; Rat

applications :

IF; IHC-P; WB

gene full name :

Retinoblastoma-associated protein

gene name :

RB1

protein function :

Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

research category :

cell biology cell cycle cell cycle inhibitors tags & cell markers subcellular markers nucleus nucleoplasm epigenetics and nuclear signaling transcription cancer susceptibility tumor suppressors cancer oncoproteins/suppressors rb family

storage :

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Nucleus .

synonyms :

Retinoblastoma-associated protein;p105-Rb;pRb;Rb;pp110;RB1;

tissue specificity :

Expressed in the retina.

uniprot id :

P06400