Anti-Phospho-Fusin (S339) CXCR4 Antibody | Boster A00031S339-1 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-Fusin (S339) CXCR4 Antibody

catalog :

A00031S339-1

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

SKU :

A00031S339-1

Product Name :

Anti-Phospho-Fusin (S339) CXCR4 Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat, Monkey

Application(s) :

WB, IHC, IF, ELISA

Application Details :

WB 1:500-1:2000.IHC 1:100-1:300.IF 1:200-1:1000 ELISA 1:20000

Description :

Boster Bio Anti-Phospho-Fusin (S339) CXCR4 Antibody catalog # A00031S339-1. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Concentration :

1 mg/ml

Gene Name :

CXCR4

Uniprot ID :

P61073

Immunogen :

Synthesized peptide derived from human Fusin around the phosphorylation site of S339.

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Annexin A1

Synonyms :

Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I

Protein Name :

Annexin A1

Molecular Weight :

38714 MW

Protein Function :

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down- regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T- cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca (2+) and can bind up to eight Ca (2+) ions (By similarity). Displays Ca (2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca (2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).

Subcellular Localization :

Nucleus

Tissue Specificity :

Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.