Anti-Phospho-p53 (T18) TP53 Antibody | Boster A00001T18 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-p53 (T18) TP53 Antibody

catalog :

A00001T18

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA

product information

SKU :

A00001T18

Product Name :

Anti-Phospho-p53 (T18) TP53 Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, ELISA

Application Details :

WB 1:500-1:2000 ELISA 1:20000

Description :

Boster Bio Anti-Phospho-p53 (T18) TP53 Antibody catalog # A00001T18. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1 mg/ml

Gene Name :

TP53

Uniprot ID :

P04637

Immunogen :

Synthesized peptide derived from human p53 around the phosphorylation site of T18.

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Collagenase 3

Synonyms :

Collagenase 3; 3.4.24.-; Matrix metalloproteinase-13; MMP-13; MMP13;

Protein Name :

Collagenase 3

Molecular Weight :

53820 MW

Protein Function :

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix

Tissue Specificity :

Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue.