Anti-Phospho-p53 (S378) TP53 Antibody | Boster A00001S378 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-p53 (S378) TP53 Antibody

catalog :

A00001S378

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA

product information

SKU :

A00001S378

Product Name :

Anti-Phospho-p53 (S378) TP53 Antibody

Size :

100 ul

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

WB, ELISA

Application Details :

WB 1:500-1:2000 ELISA 1:20000

Description :

Boster Bio Anti-Phospho-p53 (S378) TP53 Antibody catalog # A00001S378. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

1 mg/ml

Gene Name :

TP53

Uniprot ID :

P04637

Immunogen :

Synthesized peptide derived from human p53 around the phosphorylation site of S378.

Form :

Liquid

Contents :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Isotype :

IgG

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Protein S100-B

Synonyms :

Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100B;

Protein Name :

Protein S100-B

Molecular Weight :

10713 MW

Protein Function :

Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Subcellular Localization :

Cytoplasm

Tissue Specificity :

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.