Anti-Synaptopodin Antibody | Boster Immunoleader RP1069 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Synaptopodin Antibody

catalog :

RP1069

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Synaptopodin Antibody

Catalog Number :

RP1069

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Synaptopodin(SYNPO) detection. Tested with WB in Human;Mouse.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species:Human, Mouse

Notes :

WB: The detection limit for Synaptopodin is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human Synaptopodin(629-658aa EKPKVTPNPDLLDLVQTADEKRRQRDQGEV), different from the related mouse sequence by one amino acid, and identical to the related rat sequence.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Synaptopodin is also known as SYNPO. The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are thought to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important function of the spine apparatus is the regulation of plasticity at individual synapses, a process known as metaplasticity. The International Radiation Hybrid Mapping Consortium mapped the SYNPO gene to chromosome 5.

Reference :

1. Cooney; Hurlburt, JL; Selig, DK; Harris, KM; Fiala, JC (2002). "Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane". The Journal of neuroscience : the official journal of the Society for Neuroscience 22 (6): 2215–24. 2. Deller; Merten, T; Roth, SU; Mundel, P; Frotscher, M (2000). "Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons". The Journal of Comparative Neurology 418 (2): 164–81 3. Gray (1959). "Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex". Nature 183 (4675): 1592–3.

Gene Name :

SYNPO

Protein Name :

Synaptopodin

Gene Full Name :

synaptopodin

Synonyms :

KIAA1029 antibody Synaptopodin antibody SYNPO antibody SYNPO_HUMAN antibody

Uniprot ID :

Q8N3V7

more info or order :

Boster Immunoleader product webpage