Boster Immunoleader

antibody

Anti-SLC6A4 Antibody

RP1068

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse

Anti-SLC6A4 Antibody

RP1068

Polyclonal

Rabbit IgG polyclonal antibody for Sodium-dependent serotonin transporter(SLC6A4) detection. Tested with WB in Human;Mouse.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species:Human, Mouse

WB: The detection limit for SLC6A4 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human SLC6A4 (57-85aa DDTRHSIPATTTTLVAELHQGERETWGKK), different from the related mouse and rat sequences by six amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

SLC6A4 (Solute carrier family 6, member 4), also known as SERT(serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium: neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

1. Kim, S.-J., Cox, N., Courchesne, R., Lord, C., Corsello, C., Akshoomoff, N., Guter, S., Leventhal, B. L., Courchesne, E., Cook, E. H., Jr.Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder.Molec. Psychiat. 7: 278-288, 2002. 2. Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., Murphy, D. L.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.Science 274: 1527-1530, 1996. 3. Shen, S., Battersby, S., Weaver, M., Clark, E., Stephens, K., Harmar, A. J.Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes.Europ. J. Hum. Genet. 8: 75-78, 2000.

SLC6A4

Sodium-dependent serotonin transporter

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

5 HTT antibody 5 HTTLPR antibody 5 hydroxytryptamine (serotonin) transporter antibody 5 hydroxytryptamine transporter antibody 5HT transporter antibody 5HTT antibody hSERT antibody HTT antibody Na+/Cl- dependent serotonin transporter antibody OCD1 antibody SC6A4_HUMAN antibody Serotonin transporter 1 antibody SERT antibody SERT1 antibody SLC6A4 antibody Sodium dependent serotonin transporter antibody Sodium-dependent serotonin transporter antibody Solute carrier family 6 (neurotransmitter transporter) member 4 antibody solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 antibody Solute carrier family 6 member 4 antibody

P31645