Anti-EAAT2 Antibody | Boster Immunoleader RP1065 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-EAAT2 Antibody

catalog :

RP1065

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-EAAT2 Antibody

Catalog Number :

RP1065

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Excitatory amino acid transporter 2(SLC1A2) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for EAAT2 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human EAAT2 recombinant protein (Position: T461-K574). Human EAAT2 shares 96% amino acid (aa) sequence identity with both mouse and rat EAAT2.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

SLC1A2 is also known as EAAT2 or GLT-1. This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.

Reference :

1. Jiménez-Jiménez FJ, et al. The solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, rs3794087 variant and assessment risk for restless legs syndrome. Sleep Med, 2014 Feb. 2. Poletti S, et al. Effect of early stress on hippocampal gray matter is influenced by a functional polymorphism in EAAT2 in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry, 2014 Jun 3. 3. Tanaka K. Role of glutamate transporters in the pathophysiology of major mental illnesses. Nihon Yakurigaku Zasshi, 2013 Dec.

Gene Name :

SLC1A2

Protein Name :

Excitatory amino acid transporter 2

Gene Full Name :

solute carrier family 1 (glial high affinity glutamate transporter), member 2

Synonyms :

EAA2_HUMAN antibody EAAT2 antibody Excitatory amino acid transporter 2 antibody Excitotoxic amino acid transporter 2 antibody Glial high affinity glutamate transporter antibody GLT 1 antibody GLT1 antibody Glutamate aspartate transporter II antibody Glutamate transporter 1 antibody Glutamate/aspartate transporter II antibody Slc1a2 antibody Sodium dependent glutamate aspartate transporter 2 antibody Sodium-dependent glutamate/aspartate transporter 2 antibody solute carrier family 1 (glial high affinity glutamate transporter), member 2 antibody Solute carrier family 1 glial high affinity glutamate transporter member 2 antibody Solute carrier family 1 member 2 antibody

Uniprot ID :

P43004

more info or order :

Boster Immunoleader product webpage