Anti-MUC2 Antibody | Boster Immunoleader RP1038 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-MUC2 Antibody

catalog :

RP1038

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse

application :

immunohistochemistry - paraffin section

publications citing this reagent :

Yang L, Junmin S, Hong Y, Shuodong W. PGE(2) induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation. Ann Hepatol. 2013;12:479-86 pubmed

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product information

Product Name :

Anti-MUC2 Antibody

Catalog Number :

RP1038

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Mucin-2(MUC2) detection. Tested with IHC-P in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

IHC-P

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human MUC2 recombinant protein (Position: S21-W380). Human MUC2 shares 78% and 79% amino acid (aa) sequences identity with mouse and rat MUC2, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by SA1022 in IHC(P).

Background :

Mucin 2, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. This gene encodes a member of the mucin protein family. It is mapped to 11p15.5. Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium. The primary function of the MUC2 gene product is to provide a protective barrier between the epithelial surfaces and the gut lumen. There is decreased expression of MUC2 in colonic cancer and defective polymerization of secreted mucin in ulcerative colitis.

Reference :

1. Allen, A., Hutton, D. A., Pearson, J. P. The MUC2 gene product: a human intestinal mucin. Int. J. Biochem. Cell Biol. 30: 797-801, 1998. 2. Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004). "The complete genomic organization of the human MUC6 and MUC2 mucin genes". Genomics 83 (5): 936–9.

Gene Name :

MUC2

Protein Name :

Mucin-2

Gene Full Name :

mucin 2, oligomeric mucus/gel-forming

Synonyms :

Intestinal mucin 2 antibody Intestinal mucin-2 antibody MLP antibody MUC 2 antibody MUC-2 antibody Muc2 antibody MUC2_HUMAN antibody Mucin 2 antibody Mucin 2 intestinal antibody Mucin 2 intestinal/tracheal antibody Mucin 2 oligomeric mucus/gel forming antibody Mucin 2 precursor antibody Mucin 2 tracheal antibody Mucin like protein antibody Mucin-2 antibody Mucin2 antibody SMUC antibody

Uniprot ID :

Q02817

more info or order :

Boster Immunoleader product webpage