Anti-TIE2 Antibody | Boster Immunoleader RP1036 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-TIE2 Antibody

catalog :

RP1036

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-TIE2 Antibody

Catalog Number :

RP1036

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Angiopoietin-1 receptor(TEK) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

WB: The detection limit for TIE2 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human TIE2 recombinant protein (Position: Q641-I830). Human TIE2 shares 91% amino acid (aa) sequence identity with mouse TIE2.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

TIE2, also known as TEK tyrosine kinase, TIE2 gene is mapped to 9p21.2. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

Reference :

1. Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., Suda, T. Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-161, 2004. 2. Ramsden, J. D., Cocks, H. C., Shams, M., Nijjar, S., Watkinson, J. C., Sheppard, M. C., Ahmed, A., Eggo, M. C. Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3-prime,5-prime-monophosphate. J. Clin. Endocr. Metab. 86: 2709-2716, 2001.

Gene Name :

TEK

Protein Name :

Angiopoietin-1 receptor

Gene Full Name :

TEK tyrosine kinase, endothelial

Synonyms :

Angiopoietin 1 receptor antibody Angiopoietin-1 receptor antibody CD202b antibody CD202b antigen antibody CD202b antigen antibody Endothelial tyrosine kinase antibody Endothelium specific receptor tyrosine kinase 2 antibody hTIE 2 antibody hTIE 2 antibody hTIE2 antibody hTIE2 antibody Hyk antibody p140 TEK antibody p140 TEK antibody Soluble TIE2 variant 1 antibody Soluble TIE2 variant 2 antibody TEK antibody tek tyrosine kinase antibody TEK tyrosine kinase endothelial antibody tek tyrosine kinase, endothelial antibody TIE 2 antibody TIE2_HUMAN antibody Tunica interna endothelial cell kinase antibody Tyrosine kinase with Ig and EGF homology domains 2 antibody Tyrosine protein kinase receptor TEK antibody Tyrosine protein kinase receptor TIE 2 antibody Tyrosine protein kinase receptor TIE 2 antibody Tyrosine-protein kinase receptor TEK antibody Tyrosine-protein kinase receptor TIE-2 antibody Venous malformations multiple cutaneous and mucosal antibody VMCM 1 antibody VMCM antibody VMCM1 antibody

Uniprot ID :

Q02763

more info or order :

Boster Immunoleader product webpage