Anti-FOXP3 Antibody | Boster Immunoleader RP1032 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-FOXP3 Antibody

catalog :

RP1032

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

immunohistochemistry - paraffin section

publications citing this reagent :

Wang B, Dai S, Dong Z, Sun Y, Song X, Guo C, et al. The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine IL-35 in apolipoprotein E-deficient mice. PLoS ONE. 2014;9:e87787 pubmed publisher
Li G, Ren J, Wang G, Gu G, Hu D, Ren H, et al. T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease. Int Immunopharmacol. 2014;18:244-8 pubmed publisher

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-FOXP3 Antibody

Catalog Number :

RP1032

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Forkhead box protein P3(FOXP3) detection. Tested with IHC-P in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

IHC-P

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human FOXP3 recombinant protein (Position: H101-P431). Human FOXP3 shares 88% amino acid (aa) sequence identity with mouse FOXP3.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by SA1022 in IHC(P).

Background :

FOXP3(forkhead box P3) is a protein involved in immune system responses. The human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to the p arm of the X chromosome(specifically, Xp11.23). A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells. While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.

Reference :

1. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F., Roncarolo, M. G., Levings, M. K.The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.J. Clin. Invest. 115: 3276-3284, 2005. 2. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., Ochs, H. D.The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.Nature Genet. 27: 20-21, 2001. 3. Hong, J., Li, N., Zhang, X., Zheng, B., Zhang, J. Z.Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3.Proc. Nat. Acad. Sci. 102: 6449-6454, 2005.

Gene Name :

FOXP3

Protein Name :

Forkhead box protein P3

Gene Full Name :

forkhead box P3

Synonyms :

AIID antibody DIETER antibody Forkhead box P3 antibody Forkhead box protein P3 antibody foxp3 antibody FOXP3_HUMAN antibody FOXP3delta7 antibody Immune dysregulation polyendocrinopathy enteropathy X linked antibody Immunodeficiency polyendocrinopathy enteropathy X linked antibody IPEX antibody JM2 antibody MGC141961 antibody MGC141963 antibody OTTHUMP00000025832 antibody OTTHUMP00000025833 antibody OTTHUMP00000226737 antibody PIDX antibody SCURFIN antibody XPID antibody

Uniprot ID :

Q9BZS1

more info or order :

Boster Immunoleader product webpage