Boster Immunoleader

antibody

Anti-mouse IL17 Antibody

RP1019

100 ug/vial

240 USD

polyclonal

rabbit

western blot, ELISA

Anti-mouse IL17 Antibody

RP1019

Polyclonal

Rabbit IgG polyclonal antibody for Interleukin-17A(IL17A) detection. Tested with WB, ELISA in Mouse.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: mouse

WB,ELISA

Concentration: 0.1-0.5μg/ml; Species: Mouse

Concentration: 0.1-0.5μg/ml; Species: Mouse

Other applications have not been tested. Optimal dilutions should be determined by end users.

E. coli-derived mouse IL-17 recombinant protein(Position: A26-A158).

Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

IL-17(Interleukin-17), originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993, is the founding member of a group of cytokines called the IL-17 family. Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reading frame of the T-lymphotropic rhadinovirus Herpesvirus saimiri. Mouse IL-17 shares 85% amino acid sequence homology with rat. Interleukin 17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL–23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen's cellular matrix. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. To elicit its functions, IL-17 binds to a type I cell surface receptor called IL-17R of which there are at least three variants IL17RA, IL17RB, and IL17RC.

1. Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., Weaver, C. T.Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.Nature Immun. 6: 1123-1132, 2005. 2. Kennedy, J., Rossi, D. L., Zurawski, S. M., Vega, F., Jr.Kastelein, R. A.; Wagner, J. L.; Hannum, C. H.; Zlotnick, A.: Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.J. Interferon Cytokine Res. 16: 611-617, 1996. 3. Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., Martin, T. J., Suda, T.IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.J. Clin. Invest. 103: 1345-1352, 1999.

IL17A

Interleukin-17A(IL-17/IL-17A)

interleukin 17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8

CTLA 8 antibody CTLA-8 antibody CTLA8 antibody Cytotoxic T lymphocyte associated antigen 8 antibody Cytotoxic T lymphocyte associated protein 8 antibody Cytotoxic T lymphocyte associated serine esterase 8 antibody Cytotoxic T-lymphocyte-associated antigen 8 antibody IL 17A antibody IL-17 antibody IL-17A antibody IL17 antibody IL17A antibody Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody Interleukin 17A antibody Interleukin-17A antibody Interleukin17 antibodyInter leukin17A antibody OTTHUMP00000016597 antibody OTTMUSP00000046003 antibody

Q62386