Anti-Cdc37 Antibody | Boster Immunoleader PB9574 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Cdc37 Antibody

catalog :

PB9574

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Cdc37 Antibody

Catalog Number :

PB9574

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Hsp90 co-chaperone Cdc37(CDC37) detection. Tested with WB in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human Cdc37 recombinant protein (Position: M216-V378). Human Cdc37 shares 95.7% and 95.1% amino acid (aa) sequence identity with mouse and rat Cdc37, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Hsp90 co-chaperone Cdc37, also called P50CDC37, is a protein that in humans is encoded by the CDC37 gene. The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This gene is mapped to 19p13.2. And this protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.

Reference :

1. Chen, G., Cao, P., Goeddel, D. V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Molec. Cell 9: 401-410, 2002. 2. Vaughan, C. K., Mollapour, M., Smith, J. R., Truman, A., Hu, B., Good, V. M., Panaretou, B., Neckers, L., Clarke, P. A., Workman, P., Piper, P. W., Prodromou, C., Pearl, L. H.Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molec. Cell 31: 886-895, 2008.

Gene Name :

CDC37

Protein Name :

Hsp90 co-chaperone Cdc37

Gene Full Name :

cell division cycle 37

Synonyms :

CDC 37 antibody CDC37 antibody CDC37 cell division cycle 37 homolog antibody CDC37 cell division cycle 37 S cerevisiae homolog antibody Cdc37 homolog antibody CDC37 protein antibody CDC37_HUMAN antibody CDC37A antibody Cell division cycle 37 homolog antibody Hsp90 chaperone protein kinase targeting subunit antibody Hsp90 chaperone protein kinase targeting subunit p50Cdc37 antibody Hsp90 chaperone protein kinase-targeting subunit antibody Hsp90 co chaperone Cdc37 antibody Hsp90 co-chaperone Cdc37 antibody p50 antibody p50Cdc37 antibody S cerevisiae hypothetical protein CDC37 antibody S. cerevisiae hypothetical protein CDC37 antibody

Uniprot ID :

Q16543

more info or order :

Boster Immunoleader product webpage