Anti-CYP24A1 Antibody | Boster Immunoleader PB9547 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CYP24A1 Antibody

catalog :

PB9547

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-CYP24A1 Antibody

Catalog Number :

PB9547

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human CYP24A1 recombinant protein (Position: E153-R514). Human CYP24A1 shares 86.2% amino acid (aa) sequence identity with both mouse and rat CYP24A1.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. And this mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reference :

1. "Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1". 2. Dauber A, Nguyen TT, Sochett E, Cole DE, Horst R, Abrams SA, Carpenter TO, Hirschhorn JN (February 2012). "Genetic defect in CYP24A1, the vitamin D 24-hydroxylase gene, in a patient with severe infantile hypercalcemia". J. Clin. Endocrinol. Metab. 97 (2): E268–74. 3. Sakaki T, Kagawa N, Yamamoto K, Inouye K (January 2005). "Metabolism of vitamin D3 by cytochromes P450". Front. Biosci. 10: 119–34.

Gene Name :

CYP24A1

Protein Name :

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Gene Full Name :

cytochrome P450, family 24, subfamily A, polypeptide 1

Synonyms :

1 25 @dihydroxyvitamin D3 24 hydroxylase antibody 1 25 dihydroxyvitamin D(3) 24 hydroxylase antibody 1 antibody 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial antibody 24 ohase antibody 24-OHase antibody 25-dihydroxyvitamin D(3) 24-hydroxylase antibody CP 24 antibody CP24 antibody CP24A_HUMAN antibody CYP 24 antibody CYP24 antibody CYP24A1 antibody Cytochrome P450 24A1 antibody Cytochrome P450 24A1 mitochondrial antibody cytochrome P450 CC24 antibody Cytochrome P450 family 24 antibody Cytochrome P450 family 24 subfamily A polypeptide 1 antibody Cytochrome P450 subfamily XXIV antibody Cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase) antibody Cytochrome P450-CC24 antibody EC 1.14.13.n4 antibody Exo mitochondrial protein antibody HCAI antibody MGC126273 antibody MGC126274 antibody mitochondrial antibody P450 CC24 antibody Vitamin D 24 hydroxylase antibody Vitamin D(3) 24 hydroxylase antibody Vitamin D(3) 24-hydroxylase antibody

Uniprot ID :

Q07973

more info or order :

Boster Immunoleader product webpage