Anti-CYLD Antibody | Boster Immunoleader PB9543 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CYLD Antibody

catalog :

PB9543

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-CYLD Antibody

Catalog Number :

PB9543

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Ubiquitin carboxyl-terminal hydrolase CYLD(CYLD) detection. Tested with WB in Human;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human CYLD recombinant protein (Position: D618-K956). Human CYLD shares 97.6% and 97.9% amino acid (aa) sequence identity with mouse and rat CYLD, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

CYLD is localized on the long arm of chromosome 16. This gene encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Reference :

1. Hayashi M, Jono H, Shinriki S, Nakamura T, Guo J, Sueta A, Tomiguchi M, Fujiwara S, Yamamoto-Ibusuki M, Murakami K, Yamashita S, Yamamoto Y, Li JD, Iwase H, Ando Y. “Clinical significance of CYLD downregulation in breast cancer”. Breast Cancer Res Treat, 2014 Feb. 2. Vanecek T, Halbhuber Z, Kacerovska D, Martinek P, Sedivcova M, Carr RA, Slouka D, Michal M, Kazakov DV. “Large germline deletions of the CYLD gene in patients with Brooke-Spiegler syndrome and multiple familial trichoepithelioma”. Am J Dermatopathol, 2014 Nov.

Gene Name :

CYLD

Protein Name :

Ubiquitin carboxyl-terminal hydrolase CYLD

Gene Full Name :

cylindromatosis (turban tumor syndrome)

Synonyms :

BRSS antibody CDMT antibody Cyld antibody CYLD gene antibody CYLD_HUMAN antibody CYLD1 antibody CYLDI antibody cylindromatosis (turban tumor syndrome) antibody cylindromatosis 1 antibody Deubiquitinating enzyme CYLD antibody EAC antibody HSPC057 antibody KIAA0849 antibody MFT antibody MFT1 antibody Probable ubiquitin carboxyl terminal hydrolase CYLD antibody SBS antibody TEM antibody turban tumor syndrome antibody Ubiquitin carboxyl-terminal hydrolase CYLD antibody ubiquitin specific peptidase like 2 antibody ubiquitin thioesterase CYLD antibody Ubiquitin thiolesterase CYLD antibody Ubiquitin-specific processing protease CYLD antibody Ubiquitin-specific-processing protease CYLD antibody USPL2 antibody

Uniprot ID :

Q9NQC7

more info or order :

Boster Immunoleader product webpage