Anti-BMPR1B Antibody | Boster Immunoleader PB9528 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-BMPR1B Antibody

catalog :

PB9528

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunohistochemistry - paraffin section

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product information

Product Name :

Anti-BMPR1B Antibody

Catalog Number :

PB9528

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Bone morphogenetic protein receptor type-1B(BMPR1B) detection. Tested with WB, IHC-P in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human BMPR1B recombinant protein (Position: K14-Q184). Human BMPR1B shares 97.1% amino acid (aa) sequence identity with mouse BMPR1B.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

BMPR1B (Bone Morphogenetic Protein Receptor Type IB), also known as ALK6, is a protein which in humans is encoded by the BMPR1B gene. BMPR1B is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. By analysis of a monochromosome hybrid mapping panel and by FISH, Astrom et al. (1999) mapped the BMPR1B gene to chromosome 4q22-q24. Ide et al. (1997) compared BMP receptor expression in normal and cancerous prostate tissues. While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue.

Reference :

1. Astrom, A.-K., Jin, D., Imamura, T., Roijer, E., Rosenzweig, B., Miyazono, K., ten Dijke, P., Stenman, G. Chromosomal localization of three human genes encoding bone morphogenetic protein receptors. Mammalian Genome 10: 299-302, 1999. 2. Demirhan, O., Turkmen, S., Schwabe, G. C., Soyupak, S., Akgul, E., Tastemir, D., Karahan, D., Mundlos, S., Lehmann, K. A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies. J. Med. Genet. 42: 314-317, 2005. 3. Ide, H., Katoh, M., Sasaki, H., Yoshida, T., Aoki, K., Nawa, Y., Osada, Y., Sugimura, T., Terada, M. Cloning of human bone morphogenetic protein type 1B receptor (BMPR-1B) and its expression in prostate cancer in comparison with other BMPRs. Oncogene 14: 1377-1382, 1997. Note: Erratum: Oncogene 15: 1121 only, 1997.

Gene Name :

BMPR1B

Protein Name :

Bone morphogenetic protein receptor type-1B

Gene Full Name :

bone morphogenetic protein receptor, type IB

Synonyms :

Activin receptor like kinase 6 antibody Acvrlk6 antibody ALK 6 antibody ALK6 antibody alk6tr antibody BMP type-1B receptor antibody BMPR IB antibody BMPR-1B antibody Bmpr1b antibody BMPRIB antibody BMR1B_HUMAN antibody Bone morphogenetic protein receptor type 1B antibody Bone morphogenetic protein receptor type IB antibody Bone morphogenetic protein receptor type-1B antibody BR 1b antibody BR1b antibody CDw 293 antibody CDw293 antibody CDw293 antigen antibody CFK 43a antibody CFK43a antibody Serine/threonine receptor kinase antibody zALK 6 antibody zALK6 antibody

Uniprot ID :

O00238

more info or order :

Boster Immunoleader product webpage